Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi |
| |
Authors: | NH Choi GJ Choi B-S Min KS Jang YH Choi MS Kang MS Park JE Choi BK Bae J-C Kim |
| |
Institution: | Chemical Biotechnology Research Center, Korea Research Institute of Chemical Technology, Daejeon, Korea; College of Agricultural and Life Science, Chungnam National University, Daejeon, Korea; College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea; Yoosung Chemical R&T Co., Ltd., Daejeon, Korea; College of Pharmacy, Chungnam National University, Daejeon, Korea |
| |
Abstract: | Aims: To characterize antifungal principles from the methanol extract of Magnolia obovata and to evaluate their antifungal activities against various plant pathogenic fungi. Methods and Results: Four neolignans were isolated from stem bark of M. obovata as antifungal principles and identified as magnolol, honokiol, 4-methoxyhonokiol and obovatol. In mycelial growth inhibition assay, both magnolol and honokiol displayed more potent antifungal activity than 4-methoxyhonokiol and obovatol. Both magnolol and honokiol showed similar in vivo antifungal spectrum against seven plant diseases tested; both compounds effectively suppressed the development of rice blast, tomato late blight, wheat leaf rust and red pepper anthracnose. 4-Methoxyhonokiol and obovatol were highly active to only rice blast and wheat leaf rust respectively. Conclusions: The extract of M. obovata and four neolignans had potent in vivo antifungal activities against plant pathogenic fungi. Significance and Impact of the Study: Neolignans from Magnolia spp. can be used and suggested as a novel antifungal lead compound for the development of new fungicide and directly as a natural fungicide for the control of plant diseases such as rice blast and wheat leaf rust. |
| |
Keywords: | antifungal activity honokiol Magnolia obovata magnolol neolignans obovatol plant pathogen |
|
|