Enrichment of homologs in insignificant BLAST hits by co-complex network alignment |
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| Authors: | Like Fokkens Sandra MC Botelho Jos Boekhorst Berend Snel |
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| Affiliation: | 1.Theoretical Biology and Bioinformatics group, Department of Biology, Faculty of Science,Utrecht University,Utrecht,the Netherlands;2.PhD Program in Computational Biology,Instituto Gulbenkian de Ciência,Oeiras,Portugal;3.Netherlands Bioinformatics Centre,Nijmegen,the Netherlands |
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| Abstract: | Background Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stringent score cutoff is applied to distinguish putative homologs from possible false positive hits. As a consequence, some BLAST hits are discarded that are in fact homologous. |
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