Synthesis,modification, and antimicrobial activity of the <Emphasis Type="Italic">N</Emphasis>-methylpiperazinyl amides of triterpenic acids |
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| Authors: | O B Kazakova G V Giniyatullina G A Tolstikov N I Medvedeva T M Utkina O L Kartashova |
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| Institution: | 1.Institute of Organic Chemistry, Ufa Scientific Center,Russian Academy of Sciences,Ufa,Russia;2.Institute of Cellular and Intracellular Symbiosis, Ural Division,Russian Academy of Sciences,Orenburg,Russia |
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| Abstract: | N-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and
modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpyperazinyl amides, the highest activity against S. aureus was observed for a betulonic acid derivative. |
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