| O-GlcNAc修饰对蛋白质泛素化降解途径的影响 |
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| 引用本文： | 周丰,;刘晓燕,;王玉秋,;张连文. O-GlcNAc修饰对蛋白质泛素化降解途径的影响[J]. 生命科学, 2014, 0(8): 852-857 |
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| 作者姓名： | 周丰, 刘晓燕, 王玉秋, 张连文 |
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| 作者单位： | [1]天津大学药物科学与技术学院,天津300072; [2]南开大学药学院,天津300071 |
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| 基金项目： | 国家重点基础研宄发展计划（“973”项目）（2012CB910300）;国家自然科学基金项目（30970644） |
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| 摘 要： | O-GlcNAc修饰是一种特殊的糖基化修饰,几乎参与生物体内所有细胞过程的调控。该修饰与泛素化作为两种重要的蛋白质翻译后修饰形式,都与2型糖尿病、神经退行性疾病、癌症等疾病密切相关。O-GlcNAc修饰对蛋白质泛素化降解途径的影响主要体现在4个方面:(1)O-GlcNAc修饰能够抑制26S蛋白酶体的ATPase活性;(2)O-GlcNAc修饰会减少某些底物蛋白的泛素化降解;(3)O-GlcNAc修饰泛素化相关酶并调节其功能;(4)某些蛋白质(包括调控因子)发生O-GlcNAc修饰后间接影响蛋白质泛素化。
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| 关 键 词： | O-GlcNAc糖基化 泛素化 蛋白酶体途径 蛋白质间相互作用 |
O-GlcNAcylation influences ubiquitin proteasome degradation of protein |
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| Affiliation: | ZHOU Feng, LIU Xiao-Yan, WANG Yu-Qiu, ZHANG Lian-Wen. ( School of Pharmaceutical Science and Technology, Tianjin Universtiy, Tianjin 300072, China; College of Pharmacy, Nankai University, Tianjin 300071, China) |
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| Abstract: | O-GlcNAcylation is a special protein glycosylation, which plays crucial roles in various cellular events. Both O-GlcNAcylation and ubiquitination are important post-translational modification. They are closely related to type 2 diabetes, neurodegenerative diseases, cancer and other diseases. The cross-talk between O-GlcNAcylation and ubiquitination could be divided into four categories： （1） O-GlcNAcylaion of the 26S proteasome regulatory subunit inhibits its ATPase activity; （2） O-GlcNAcylaion on some proteins could decrease their ubiquitin proteasome degradation; （3） O-GlcNAcylation of ubiquitination enzymes regulates their functions; （4） O-GlcNAcylation on some protein （including regulatory factors） affects ubiquitination process indirectly. |
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| Keywords: | O-GlcNAcylation ubiquitination UPP cross-talk |
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