| miRNA在疼痛相关离子通道及受体中的作用研究 |
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| 引用本文： | 邱芳,;刘玉强,;胡旺平,;杨之帆.miRNA在疼痛相关离子通道及受体中的作用研究[J].生命科学,2014(9):967-973. |
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| 作者姓名： | 邱芳 ;刘玉强 ;胡旺平 ;杨之帆 |
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| 作者单位： | [1]湖北大学生命科学学院,武汉430062; [2]武汉大学基础医学院生理学系,武汉430071; [3]湖北科技学院药学院,咸宁437000 |
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| 基金项目： | 基金项目：国家自然科学基金项目（31272050）：教育部新世纪人才支持计划 |
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| 摘 要： | miRNA广泛表达于神经系统,与疼痛的发生、发展密切相关。近年来研究表明,抑制miRNA的合成调制伤害性神经元对炎症刺激的反应。疼痛时,背根神经节(DRG)上miRNA明显下调,该变化参与炎性疼痛和神经性疼痛的产生和维持。同时,miRNA也可以下调Navα亚基、ASIC3、TRPV1和P2X7mRNA的表达水平,还可以降低Kv电流。因此,miRNA可能成为疼痛治疗的新靶点。综述了miRNA的生物起源、分布,及其对痛觉相关离子通道Nav、Kv、ASICs、TRPV1以及嘌呤受体的调节作用。
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| 关 键 词： | miRNA 痛觉 离子通道 嘌呤受体 |
The role of miRNA in pain-related ion channels and receptors |
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| Institution: | QIU Fang, LIU Yu-Qiang, HU Wang-Ping, YANG Zhi-Fan (1 Colllege of Life Sciences, Hubei University, Wuhan 430062, China; 2 Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; 3 Department of Pharmacology, Hubei University of Science and Technology, Xianning 437100, China) |
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| Abstract: | miRNA is widely expressed in the nervous system and is closely related to the genesis and development of pain. Recently, studies have demonstrated that inhibition of miRNA synthesis can mediate the response of nocieptive nerve to inflammatory stimulation. In the dorsal root ganglion （DRG）, rniRNA is greatly down-regulated following pain, which is involved in the induction and maintenance of inflammatory and neuropathic pain. Meanwhile, miRNA can decrease the mRNA expression levels of the Navct subunits, A SIC3, TRPV1 and P2X7, and down-regulate the current of KV. So miRNA may provide a novel target for the treatment of pain. This article highlights the miRNA biogenesis, distribution, and its significant role in pain-related ion channels （Nav, Kv, ASICs, TRPV1 and purinergic receptor）. |
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| Keywords: | miRNA pain ion channel purin receptor |
| 本文献已被 CNKI 维普 等数据库收录！ |
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