| miR-92a家族与肿瘤关系的研究进展 |
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| 引用本文： | 李墨林,;关兴芳,;孙宇强,;李传刚,;王雪,;舒晓宏. miR-92a家族与肿瘤关系的研究进展[J]. 生命科学, 2014, 0(7): 756-761 |
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| 作者姓名： | 李墨林, 关兴芳, 孙宇强, 李传刚, 王雪, 舒晓宏 |
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| 作者单位： | [1]大连医科大学病理生理学教研室,大连116044; [2]大连医科大学2010级医疗系,大连116044; [3]大连医科大学2009级七年制,大连116044; [4]大连医科大学附属二院泌尿外科,大连116023; [5]大连医科大学药学院,大连116044 |
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| 基金项目： | 基金项目：国家自然科学基金项目（81072063）：大连市科技计划项目基金项目（2012E15SF1591 |
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| 摘 要： | miR-92a家族基因是由miR-25、miR-92a~1、miR-92a~2和miR-363等序列相似、结构相仿、种子区序列相同的微小RNA(microRNAs)组成,它们分别来自在进化过程中高度保守并互为旁系同源序列的miR-106b~25、miR-17~92和miR-106a~363基因簇。目前研究认为,miR-92a家族基因是一组与血管内皮细胞形成有关的miRNAs,其表达紊乱与肿瘤的发生发展密切相关。就miR-92a家族基因及其靶基因与肿瘤关系的研究进展进行综述。
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| 关 键 词： | 肿瘤 miR-92a家族 靶基因 调控机制 |
Progress of miR-92a family in tumorigenesis |
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| Affiliation: | LI Mo-Lin, GUAN Xing-Fang, SUN Yu-Qiang, LI Chuan-Gang, Wang Xue, SHU Xiao-Hong (1 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China; 2 Grade 2010, Clinical Medicine, Dalian Medical University, Dalian 116044, China; 3 Grade 2009, Seven-year Program of Clinical Medicine, Dalian Medical University, Dalian 116044, China; 4 Division of Urology, Department of Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China; 5 College of Pharmacy, Dalian Medical University, Dalian 116044, China) |
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| Abstract: | miR-92a family is composed of 4 miRNAs in cluding miR-25, miR-92a-1, miR-92a-2 and miR-363, which share same seed region and similar sequence and structure. They arise from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conserved in the process of evolution. It was thought that miR-92a family was a group of miRNA correlated with formation of endothelial cells. It was demonstrated that the disturbance of the expression of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress of the relationship between miR-92a family and their target genes and malignant tumors is summarized. |
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| Keywords: | tumor miR-92a family target genes regulatory mechanism |
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