胶原蛋白IV的生物学特性研究进展

突破周围包裹的基底膜(BMs)向邻近或远隔部位侵袭和转移是恶性肿瘤的特征之一。因此,研究BMs主要成分——胶原蛋白IV(IV-C)的生物学特性对于预测及判断恶性肿瘤的侵袭和转移具有重要意义。IV-C不但构成BMs骨架,而且还能与细胞膜上的受体相互作用,参与细胞黏附、迁移、生长、增殖和分化等重要生理过程,与肿瘤等多种重大疾病密切相关。综述了IV-C的生物学特性研究进展。

Research progress of molecular and biological characteristics of type IV collagen

Invasion and migration after breakthrough of the basement membranes （BMs） is the characteristic of tumor. For prediction and detection of invasion and migration of tumor, it is of great significance to study type IV collagen （IV-C）, which is the major component of BMs. IV-Cs do not only assemble to provide a scaffold for BMs, but also play an important role in basement membrane-cell interaction, which is critical for a variety of biological processes, including cell adhesion, migration, growth, proliferation and differentiation, which are associated with many diseases, such as tumor. In this paper, the molecular and biological characteristics of IV-C are reviewed, which will contribute to understanding of the key role of IV-C.