| 哺乳动物生物钟与能量代谢的相关研究进展 |
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| 引用本文： | 王楠,袁拿特,富浩轩,朱雅丽,吴涛.哺乳动物生物钟与能量代谢的相关研究进展[J].生命科学,2014(9):925-930. |
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| 作者姓名： | 王楠 袁拿特 富浩轩 朱雅丽 吴涛 |
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| 作者单位： | 浙江工业大学生物与环境工程学院,杭州310014 |
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| 基金项目： | 基金项目：国家自然科学基金青年科学基金项目（31200890）;浙江省新苗人才计划项目（2013R403046） |
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| 摘 要： | 生物钟广泛存在于各种生物体中,是生命体的一种内源调节机制。哺乳动物生物钟系统与机体营养代谢和能量平衡有着密切的关系。概述了生物钟系统通过营养途径、限速酶途径、核受体途径对哺乳动物机体代谢活动和能量平衡的调控,以及哺乳动物代谢稳态对生物钟系统的影响,从而为从生物钟调控的角度治疗和防控代谢综合征提供新的思路。
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| 关 键 词： | 生物钟 代谢稳态 能量平衡 |
Advances on the relationship between circadian clock and metabolism in mammals |
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| WANG Nan,YUAN Na-Te,FU Hao-Xuan,ZHU Ya-Li,WU Tao.Advances on the relationship between circadian clock and metabolism in mammals[J].Chinese Bulletin of Life Sciences,2014(9):925-930. |
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| Authors: | WANG Nan YUAN Na-Te FU Hao-Xuan ZHU Ya-Li WU Tao |
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| Institution: | (College of Biological and Environmental Engineering, Zhej iang University of Technology, Hangzhou 310014, China) |
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| Abstract: | Circadian clock is an endogenous regulating mechanism involved in almost all eukaryotes. Recent evidence has shown close relationship among the mammalian circadian system, energy balance, and nutrient metabolism. This article briefly reviews the function of mammalian circadian system in regulating nutrient metabolism and energy homeostasis by the nutrient sensors, rate-limiting enzymes, and/or the nuclear receptors. Moreover, the role of mammalian metabolism homeostasis in circadian regulation is also stated. These findings may provide new ideas in the prevention and treatment of metabolic syndromes. |
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| Keywords: | circadian clock metabolism homeostasis energy balance |
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