| 多发性硬化和视神经脊髓炎的体液免疫机制及其干预策略 |
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| 引用本文： | 徐雁,崔丽英. 多发性硬化和视神经脊髓炎的体液免疫机制及其干预策略[J]. 生命科学, 2014, 0(6): 657-664 |
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| 作者姓名： | 徐雁 崔丽英 |
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| 作者单位： | 中国医学科学院北京协和医院神经科,北京100730 |
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| 摘 要： | 多发性硬化(multiple sclerosis,MS)和视神经脊髓炎(neuromyeltis optica,NMO)是两个独立的中枢神经系统炎性脱髓鞘疾病,B细胞和体液免疫在二者发生发展中发挥了重要作用。越来越多证据显示,针对B细胞和/或抗体的治疗有可能同时对抗MS和NMO。就B细胞及其体液免疫在MS和NMO发生发展及治疗中的作用做一综述。
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| 关 键 词： | 多发性硬化 视神经脊髓炎 体液免疫 |
The role of humoral autoimmunity in multiple sclerosis and neuromyelitis optica and therapeutic strategy |
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| XU Yan,CUI Li-Ying. The role of humoral autoimmunity in multiple sclerosis and neuromyelitis optica and therapeutic strategy[J]. Chinese Bulletin of Life Sciences, 2014, 0(6): 657-664 |
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| Authors: | XU Yan CUI Li-Ying |
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| Affiliation: | (Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China) |
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| Abstract: | Multiple sclerosis （MS） and neuromyelitis optica （NMO） are two different inflammatory demyelinating diseases in central nervous system. B cells and humoral immune responses play an important role in the immunopathogenesis of MS and NMO. There is growing evidence that treatments specifically targeting B cells and/ or antibodies are effective in both MS and NMO. This review therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO. |
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| Keywords: | multiple sclerosis neuromyelitis optica humoral autoimmunity |
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