|
|||||
|
|
Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells |
|
| Authors: | Hongwei Zhang Lingling Xian Zhiyi Lin Chaozhe Yang Meng Zhang Wenlei Feng Xinyu Peng Xueling Chen Xiangwei Wu |
| Affiliation: | 1. Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China 2. Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, North 2th Road, Shihezi, 832008, Xinjiang, China 3. Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA 4. First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, 832008, Xinjiang, China 5. Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC, 20010, USA 6. Department of Immunology, School of Medicine, Shihezi University, Shihezi, 832002, Xinjiang, China |
| Abstract: | Stem cells dwell at the “stem cell niche” to accomplish a series of biological processes. The composition of the niche should be determined because the insufficient understanding of this feature limits the development in the study of stem cells. We showed in our study on mesenchymal stem cells (MSCs) that the MSCs first neighbored to CD31+ cells, which proved to be endothelial progenitor cells (EPCs), and formed a group of cell colony before they exerted their biological functions. It was further proved that EPCs have close interactions with MSCs and promoted the self-renewal of the MSCs in vitro and in vivo. Together with these achievements, we hypothesized that EPCs may be a possible biological component of the MSC stem cell niche and affect the biological processes of MSCs. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |