Characterization of seven DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization |
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Authors: | Rina Plattner Nyla A. Heerema Shivanand R. Patil Patricia N. Howard-Peebles Catherine G. Palmer |
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Affiliation: | (1) Department of Medical Genetics, Indiana School of Medicine, 975 West Walnut Street, 46202 Indianapolis, IN, USA;(2) Department of Pediatrics, University of Iowa, 52242 Iowa City, IA, USA;(3) Genetics and IVF Institute, 3020 Javier Road, 22031 Fairfax, VI, USA;(4) Department of Medical Genetics, Medical College of Virginia, Richmond, Virginia, USA |
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Abstract: | Summary Seven dicentric bisatellited marker chromosomes, ascertained at amniocentesis, chorionic villus sampling, and in blood from an abnormal liveborn were characterized cytogenetically. All seven markers demonstrated brilliant bands by the DA/DAPI technique corresponding to C-band positive regions. Although some dicentric DA/DAPI-positive bisatellited markers have been identified as inverted duplicated 15s, recent literature has suggested that DA/DAPI lacks specificity for chromosome 15. Our evaluation of DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization shows that some originate from chromosome 15 whereas DA/DAPI negative bisatellited markers may not be derived from 15. The morphological variations noted in our studies are discussed with respect to nomenclature. |
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