88例女性小细胞肺癌临床特征分析

目的了解女性小细胞肺癌的临床特征分布。方法收集2006年1月至2012年11月大连医科大学附属二院收治的341例小细胞肺癌女性患者88例的临床资料,分析患者在年龄、分期、就诊症状、体重下降、吸烟、家族史、肿瘤位置、治疗方式、疗效反应等方面的特征。结果 2006-2012年该院女性小细胞肺癌住院患者数呈上升趋势;女性患者平均患病年龄为（57.8±11.2）岁,小于同期男性患者（60.4±10.3）岁;女性〈65岁患者比例高于男性患者（73.9%vs 67.5%）,两者比较差异有统计学意义（P=0.018）;女性患者吸烟只有13.6%,远远低于男性患者吸烟比例（85.5%）,两者比较差异有统计学意义（P=0.000）;女性家族史、体重下降、就诊症状、肿瘤位置、分期、疗效以及治疗方式的选择均与男性无差别。在广泛期小细胞肺癌中观察到女性最常见的远处转移是肝转移（40.0%）,男性肝转移只占22.2%,两者比较差异有统计学意义（P=0.036）。结论女性小细胞肺癌数一直呈上升趋势;女性小细胞肺癌就诊的平均年龄小于男性患者;在中青年小细胞肺癌中女性常见;女性吸烟患者较少;相对于男性患者,女性更常见于肝转移。

Clinical analysis of 88 female patients with small cell lung cancer

Objective To understand the epidemiological characteristics of female small cell lung cancer. Methods The clinical data of 341 cases of small cell lung cancer patients in the Second Affiliated Hospital of Dalian Medical University from 2006 January to 2012 November were collected, there were 88 female patients, analysis the age, staging, symptoms, weight loss, smoking, family history, tumor location, treatment, and curative effect. Results The number of female small cell lung cancer patients showed a rising trend in our hospital, the average age of female patients was 57. 8 years old, less than male patients （60.4 years old）. Under 65 years the proportion of female patients was higher than male patients （73.9% vs 67.5% ）, there were significant difference （P =0.018）. Female smokers only 13.6%, was far lower than the proportion of 85.5% of male patients, there was a significant difference between the two comparison （P=-. 0130）. Female family history, weight loss, clinic symptoms, tumor location, staging, curative effect and treatment options were no difference with the male. It was observed that in extensive stage women the most common metastasis was the liver metastasis （40%）, and the male accounted for only 22. 2%, two comparison with statistical difference （P=0.036）. Conclusion The number of women in small cell lung cancer has been rising; The average age of female is less than male patients; in the young small cell lung cancer women was common; Female smokers are less; Compared with male patients, female mere common in liver metastasis.