Synthesis and evaluation of daunorubicin-paclitaxel dimers |
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| Authors: | Kar A K Braun P D Wandless T J |
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| Institution: | Department of Chemistry, Stanford University, CA 94305-5080, USA. |
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| Abstract: | Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines. |
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