Position of the human X inactivation center on Xq |
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| Authors: | Eeva Therman Gloria E Sarto Catherine G Palmer Hanna Kallio Carter Denniston |
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| Institution: | (1) Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA;(2) Department of Obstetrics and Gynecology, The Prentice Women's Hospital and Maternity Center, Northwestern University, Chicago, Illinois, USA;(3) Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA |
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| Abstract: | Summary In three women with a 46,XXq- chromosome constitution, the length of the deletion was expressed as the ratio of the remaining part of Xq to Xp
. In one of them (KH) this ratio was 0.33, in another (GE) 0.59, and in the third (AP) the ratio fell between these values. The break in KH is more or less on the border of the Q-dark proximal region. A comparison with relevant X-autosomal translocations indicates that the X inactivation center lies near, but not at the border of, the Q-dark and the adjoining bright region (c and d). |
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