The role of ATPase activity in the function of molecular chaperones and some regulatory proteins]

It has been suggested that the ATPase activity of molecular chaperones depends on the structure of the recognizable determinant in the target protein. The role of molecular chaperones in polypeptide chain folding and protein association into oligomeric complexes is discussed. The putative regulatory role of the determinant ATPase activity of molecular chaperones and those of some regulatory proteins are discussed. A hypothesis is proposed that determinant ATPases play a part in the increasing specificity of intermacromolecular interactions.