X-ray diffraction study of the zinc(II) binding sites in yeast phenylalanine transfer RNA preferential binding of zinc to guanines in purine-purine sequences期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

X-ray diffraction study of the zinc(II) binding sites in yeast phenylalanine transfer RNA preferential binding of zinc to guanines in purine-purine sequences

Authors:	John R. Rubin Jiahuai Wang M. Sundaralingam

Affiliation:	Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706 U.S.A.

Abstract:	An X-ray diffraction study of a zinc(II) complex of tRNA^Phe from yeast reveals the presence of five zin-binding sites on the tRNA molecule. Two of the cooperatively bound Mg²⁺ in the native tRNA structure are replaced by Zn²⁺. The remaining sites involve direct coordination of zinc to the N7 position of tRNA guanine bases, G15, G43 and G45. Thus, zinc displays a high specificity for binding to guanine bases in purine-purine sequences.

Keywords:	X-ray diffraction Zn binding Purine-purine sequence
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