In vivo lipogenesis and enzyme levels in adipose and liver tissues from pair-fed genetically obese and lean rats |
| |
Authors: | R J Martin |
| |
Affiliation: | Animal Science Department The Pennsylvania State University University Park, Pennsylvania 16802, USA |
| |
Abstract: | Genetically obese Zucker rats pair-fed to lean controls were similar in body weight and food intake, however, epididymal fat pads were considerably larger than lean controls. incorporation of acetate-14C into adipose tissue lipid was not significantly different, however, liver lipogenesis was elevated in the obese rat. Characterization of enzyme profiles in both liver and adipose tissues revealed that enzymes normally associated with lipogenesis were elevated in liver tissue from obese rats. Malic enzyme and citrate cleavage enzyme were both depressed in adipose tissue of obese animals. From these data, it appears that the liver may be prominently involved in the development of excessive blood lipid and enlarged fat cells in the Zucker obese rat. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|