Induction of oral dyskinesias in naive rats by D1 stimulation |
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| Authors: | H Rosengarten J W Schweitzer A J Friedhoff |
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| Affiliation: | Millhauser Laboratories, Department of Psychiatry New York University School of Medicine 550 First Avenue, New York, N.Y. 10016, USA |
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| Abstract: | Repetitious opening and closing of the mouth and high frequency clonic jaw movements were observed in rats challenged with dopamine agonists after acute treatment with sulpiride or a low dose of spiroperidol. SKF 38393, a specific D1 receptor agonist, alone, also induced these behaviors and cis-flupenthixol blocked them, evidence suggesting D1 dopamine receptor mediation. |
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