HBV genotypes and antiviral-resistant variants in HBV infected subjects in Northern Italy |
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| Authors: | Medici Maria Cristina Aloisi Annalisa Martinelli Monica Abelli Laura Anna Casula Francesca Valcavi Pierpaolo Dettori Giuseppe Chezzi Carlo |
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| Institution: | Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy. mariacristina.medici@unipr.it |
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| Abstract: | HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects. |
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