Overlapping Cardiac Programs in Heart Development and Regeneration |
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| Authors: | Yi-Song Zhen Qing Wu Cheng-Lu Xiao Nan-Nan Chang Xu Wang Lei Lei Xiaojun Zhu Jing-Wei Xiong |
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| Institution: | 1. Institute of Molecular Medicine, Peking University, Beijing 100871, China;State Key Laboratory of Cardiovascular Disease, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China
2. Institute of Molecular Medicine, Peking University, Beijing 100871, China |
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| Abstract: | Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine,one of the most urgent clinical needs for heart failure.Here we present a review on zebrafish heart development and regeneration,with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart,as well as cellular and molecular programs in adult zebrafish heart regeneration.We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration.A brief perspective highlights several important and promising research areas in this exciting field. |
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| Keywords: | Cardiac progenitors Heart development Heart regeneration Zebrafish |
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