CC趋化因子配体2与肝疾病

近年来CC趋化因子配体2(chemokine(C-C motif)ligand 2,CCL2)在肝脏疾病发病机制中的作用越来越受到重视.大量研究表明,CCL2在各种肝损伤中表达上调.CCL2是炎症反应的主要调节因子,通过与其受体CCR2相互作用,使血液中的单核细胞穿过血管内皮向炎症部位迁移.白色脂肪组织分泌的CCL2能直接诱导肝细胞的脂肪聚集,与非酒精性肝病的发病机理密切相关.肝实质细胞分泌的CCL2能激活并募集肝星形细胞,参与肝纤维化甚至肝硬化的形成.CCL2能介导肝癌细胞的转移和浸润,刺激肿瘤血管生成,其与肿瘤的关系也成为研究的热点.本文将阐述CCL2与病毒性肝炎、酒精性肝炎、非酒精性脂肪性肝炎、肝纤维化、肝硬化和肝癌的研究进展.

Roles of C-C motif Chemokine Ligand 2 (CCL2) in Liver Diseases

C-C motif chemokine ligand 2 (CCL2) is a key mediator of inflammatory response. It has received increasing attention in the pathogenesis of liver diseases in recent years. A large number of studies have shown that CCL2 up expressed following various liver injuries. Through the interaction with its receptor CCR2, CCL2 induces monocyte migration from the blood stream of the vascular endothelium to the concentrated sites of inflammation. The CCL2 secreted by white adipose tissue (WAT) induces the lipid accumulation in hepatocytes, and contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). Hepatocytes-derived CCL2 activates and recruits HSC, and participates in the formation of liver fibrosis and cirrhosis. The ability of CCL2 to promote tumor metastasis/invasion and angiogenesis has become very interesting in tumor research. This paper introduces the research progress of CCL2 in viral hepatitis, alcoholic hepatitis, non-alcoholic steatohepatitis, liver fibrosis, cirrhosis and hepatocellular carcinoma.