Peptide–peptoid hybrids based on (1–11)‐parathyroid hormone analogs |
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| Authors: | A. Caporale E. Schievano E. Peggion |
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| Affiliation: | Department of Chemical Sciences, Institute of Biomolecular Chemistry, CNR, University of Padova, Padova, Italy |
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| Abstract: | A series of peptide–peptoid hybrids, containing N‐substituted glycines, were synthesized based on the H‐Aib‐Val‐Aib‐Glu‐Ile‐Gln‐Leu‐Nle‐His‐Gln‐Har‐NH2 (Har = Homoarginine) as the parent parathyroid hormone (1–11) analog. The compounds were pharmacologically characterized in their agonistic activity at the parathyroid hormone 1 receptor. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd. |
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| Keywords: | N‐substituted glycine peptidomimetics PTH analogs conformation bioactivities |
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