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Molecular mechanism of allosteric communication in the human PPARα‐RXRα heterodimer
Authors:Tuomas Venäläinen  Ferdinand Molnár  Chris Oostenbrink  Carsten Carlberg  Mikael Peräkylä
Institution:1. Laboratory of Chemistry, Department of Biosciences, University of Kuopio, Kuopio FIN‐70211, Finland;2. Laboratoire de Biologie et de Génomic Structurale, Institut de Génétique et de Biologie Moléculaire et Celullaire, Illkirch 67400 Cedex, France;3. Department of Pharmaceutics, University of Kuopio, Kuopio, FIN‐70211, Finland;4. Computational Medicinal Chemistry and Toxicology, Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit, Amsterdam, The Netherlands;5. Life Sciences Research Unit, FSTC, University of Luxembourg, Luxembourg, L‐1511, Finland;6. Laboratory of Biochemistry, Department of Biosciences, University of Kuopio, Kuopio, FIN‐70211, Finland
Abstract:
Keywords:molecular dynamics  nuclear receptors  protein‐protein interactions  point mutations  activation
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