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Mitotic CDK Promotes Replisome Disassembly,Fork Breakage,and Complex DNA Rearrangements
Authors:Lin Deng  R Alex Wu  Remi Sonneville  Olga V Kochenova  Karim Labib  David Pellman  Johannes C Walter
Institution:1. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Cell Biology, Harvard Medical School, Blavatnik Institute, Boston, MA 02115, USA;3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA 02115, USA;4. MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK;5. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;6. Howard Hughes Medical Institute, Boston, MA 02115, USA
Abstract:
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  • Keywords:DNA replication  replication stress  CMG  fork collapse  TRAIP  premature mitotic entry  template switching  genome rearrangement
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