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On the diversity of physicochemical environments experienced by identical ligands in binding pockets of unrelated proteins |
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| Authors: | Abdullah Kahraman Richard J Morris Roman A Laskowski Angelo D Favia Janet M Thornton |
| Institution: | 1. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom;2. Swiss Federal Institute of Technology Zurich, Institute of Molecular Systems Biology, Wolfgang‐Pauli Strasse 16, 8106 Zurich, Switzerland;3. John Innes Centre, Computational and System Biology, Norwich Research Park, Norwich NR7 7UH, United Kingdom;4. Istituto Italiano di Tecnologia (IIT), Drug Discovery and Development, Via Morego 30, 16163 Genoa, Italy |
| Abstract: | |
| Keywords: | molecular recognition protein– ligand interaction electrostatics hydrophobicity noncomplementarity cognate ligand protein function redox potential |