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Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition
Authors:Peng Wu  Tongtong Zhang  Baoyu Liu  Panyu Fei  Lei Cui  Rui Qin  Huaying Zhu  Danmei Yao  Ryan J. Martinez  Wei Hu  Chenyi An  Yong Zhang  Junwei Liu  Jiawei Shi  Juan Fan  Weiwei Yin  Jie Sun  Chun Zhou  Jizhong Lou
Affiliation:1. Department of Neurobiology, Institute of Neuroscience, and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;2. School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China;3. Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310058, China;4. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;5. Key Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;6. Coulter Department of Biomedical Engineering, Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA;7. State Key Laboratory of Molecular Biology, Chinese Academy Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai 200031, China;8. Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA 30322, USA;9. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Modern Optical Instrumentation, Zhejiang University, Hangzhou 310058, China;10. Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;11. Department of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;12. School of Public Health and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;13. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, and First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;14. University of the Chinese Academy of Sciences, Beijing 100049, China
Abstract:
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  • Keywords:TCR  pMHC  mechano-regulation  antigen recognition  catch bonds  molecular dynamics simulations  single molecule biophysics  TCR triggering  conformational change  immunotherapy
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