Pathway Palette: A rich internet application for peptide‐, protein‐ and network‐oriented analysis of MS data |
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| Authors: | Manor Askenazi Shaojuan Li Saurav Singh Jarrod A. Marto |
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| Affiliation: | 1. Department of Cancer Biology, Dana‐Farber Cancer Institute, Boston, MA, USA;2. Blais Proteomics Center, Dana‐Farber Cancer Institute, Boston, MA, USA;3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA;4. Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel;5. These authors have contributed equally to this work. |
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| Abstract: | Recent improvements in proteomic technologies have collectively yielded data sets that far exceed the capabilities of typical low‐throughput interpretation strategies. Unfortunately, tools designed to leverage the “peptide‐centric” content of MS‐based proteomics lag the current rate of data production. Here, we describe Pathway Palette ( http://blaispathways.dfci.harvard.edu ), a freely accessible internet application that enables researchers to easily transition from peptides to biological pathways, while simultaneously retaining the qualitative and quantitative aspects of the underlying MS data. |
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| Keywords: | Bioinformatics Mass Spectrometry proteomics Network analysis Protein– protein interaction Quantitative proteomics Rich internet application |
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