Lyonin A, a new 9,10-Secograyanotoxin from Lyonia ovalifolia |
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| Authors: | Wu Zhao-Yuan Li Hai-Zhou Wang Wei-Guang Li Hong-Mei Chen Rui Li Rong-Tao Luo Huai-Rong |
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| Affiliation: | 1. The College of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650224, P.?R. China (phone: +86‐871‐3856880;2. fax: +86‐871‐3801956);3. The College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, P.?R. China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P.?R. China |
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| Abstract: | Phytochemical studies on the branches and leaves of Lyonia ovalifolia yielded a new grayanane diterpenoid, lyonin A ( 1 ), together with two known compounds, secorhodomollolides A and D ( 2 and 3 , resp.). The structure of 1 was elucidated by combination of 1D‐ and 2D‐NMR, and MS analyses. Compound 1 turned out to be a new, highly O‐acylated grayanane diterpenoid, of which ring B has undergone an oxidative cleavage between C(9) and C(10), yielding a system differing from the previously reported grayanane type with a 5/7/6/5 ring system. Results of the cAMP regulation activity assay showed that compounds 2 and 3 at 50 μM induced a significantly decreased cAMP level in N1E‐115 neuroblastoma cells (p<0.001), indicating neuropharmacological potential. |
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| Keywords: | Lyonia ovalifolia Grayanane diterpenoids Lyonin A Diterpenoids Secorhodomollolides A and D cAMP Regulation activity |
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