Disruption of pituitary-ovarian axis by carbofuran in catfish, Heteropneustes fossilis (Bloch) |
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Authors: | Sudipta Chatterjee Asok Kumar Dasmahapatra Rama Ghosh |
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Institution: | 1. Department of Animal physiology, Bose Institute, P-1/12 CIT Scheme VII-M, Calcutta 700 054, India;2. NIEHS Marine and Freshwater Biomedical Sciences Center, University of Wisconsin-Milwaukee, 600 East Greenfield Avenue, Milwaukee, WI 53204, USA |
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Abstract: | We investigated whether carbofuran (CF), a carbamate pesticide, at sub-lethal concentration had any adverse effects on reproductive function of the Indian catfish, Heteropneustes fossilis. 17β-Estradiol content of serum and ovary of pre-spawning (P) and spawning (S) fish was reduced after sub-lethal concentration of carbofuran treatment (0.5–2 mg/ml, 30 days). After 30 days of CF treatment, the serum and ovarian vitellogenin levels of fish at the P stage were also reduced but remained unaltered in the S stage. The staining intensity of the pituitary gonadotrophs of the pre-spawning fish was significantly higher in CF-treated fish compared to controls suggesting the inability of the pituitary gonadotrophs to release gonadotropin following CF treatment. CF thus acts as an antiestrogenic, endocrine-disrupting agent in fish, possibly targeting the pituitary-gonad axis. |
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Keywords: | Catfish Carbofuran Pituitary Estrogen Vitellogenin |
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