| 赖氨酰氧化酶与人类疾病 |
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| 引用本文： | 张艳君,蒋稼欢,谢 静,杨 力,宋国立. 赖氨酰氧化酶与人类疾病[J]. 生物化学与生物物理进展, 2011, 38(5): 389-399 |
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| 作者姓名： | 张艳君 蒋稼欢 谢 静 杨 力 宋国立 |
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| 作者单位： | “生物流变科学与技术”教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044;“生物流变科学与技术”教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044;“生物流变科学与技术”教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044;“生物流变科学与技术”教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044;“生物流变科学与技术”教育部重点实验室(重庆大学)，重庆大学生物工程学院，重庆 400044；Departments of Orthopedics and Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA |
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| 基金项目： | “111计划”资助项目(B06023), 重庆市科技攻关计划资助项目(CSTC, 20085129) |
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| 摘 要： | 赖氨酰氧化酶(lysyl oxidases,LOXs)是一种能够催化细胞外基质蛋白(如胶原和弹性蛋白)交叉连接的酶类,这一功能使其在组织的稳定、重塑和伤口愈合中发挥重要作用.随着研究的不断深入,LOXs在细胞增殖、细胞趋化以及肿瘤发生等过程中也彰显出十分关键的作用.研究发现,一些诸如结缔组织病、剥脱综合症、铜代谢障碍性疾病及盆腔器官脱垂和骨疾等疾病的发生与LOXs有很大关系.综述了LOXs的生物合成、结构特点、多功能性以及与人类疾病的关系.
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| 关 键 词： | 赖氨酰氧化酶 细胞外基质 交叉连接 重塑 伤口愈合 |
| 收稿时间： | 2010-09-09 |
| 修稿时间： | 2010-11-27 |
Lysyl Oxidases Related to Human Diseases |
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| ZHANG Yan-Jun,JIANG Jia-Huan,XIE Jing,YANG Li and SUNG KL Paul. Lysyl Oxidases Related to Human Diseases[J]. Progress In Biochemistry and Biophysics, 2011, 38(5): 389-399 |
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| Authors: | ZHANG Yan-Jun JIANG Jia-Huan XIE Jing YANG Li SUNG KL Paul |
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| Affiliation: | Key Laboratory of Biorheological Science and Technology(Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;Key Laboratory of Biorheological Science and Technology(Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;Key Laboratory of Biorheological Science and Technology(Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;Key Laboratory of Biorheological Science and Technology(Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;Key Laboratory of Biorheological Science and Technology(Chongqing University), Ministry of Education,Bioengineering College, Chongqing University, Chongqing 400044, China;Departments of Orthopedics and Bioengineering, University of California at San Diego, La Jolla, CA 92093, USA |
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| Abstract: | Lysyl oxidases (LOXs) are a family of anabolic enzymes that function to maintain, heal, and remodel tissue architecture by cross linking the extracellular matrix proteins, collagens and elastins. In a series of studies, LOXs have been considered as a family of multi-functional enzymes, which play an essential role in cell proliferation, cell chemotactical responses and tumor genesis. LOXs have now been implicated in several pathological conditions including connective tissue disease, exfoliation syndrome, disorders of copper metabolism, pelvic organ prolapse and bone disorders, so on. Its biosynthesis, structure characteristics, multi-function and relationship between LOXs and human diseases were summarized. |
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| Keywords: | lysyl oxidase extra cellular matrix matrix crosslink remodeling tissue healing |
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