非编码RNA与RNA组学研究现状及发展态势

人类基因组计划的完成(2001年)宣告了后基因组时代的到来，也掀起新一轮的RNA研究热潮．作为后基因组时代的科学前沿，RNA组学近年来成为生命科学领域的研究热点，各种新型ncRNA的发现，让人们对遗传信息表达调控网络有了新的认识．结合RNA领域的最新研究进展，《 中国科学C辑：生命科学》 (Science in China Series C-Life Sciences)2009年第3期的8篇述评，从动植物小分子非编码 RNA、miRNA 与细胞分化发育、miRNA 与肿瘤发生及诊断治疗的靶点、核酶的结构与功能、遗传印记起源、miRNA 基因簇的进化等多个方面进行了综述，展现了ncRNA领域的研究现状和发展前景．

The Recent Progress of Non-coding RNA and RNomics

The completion of the Human Genome Project (HGP) in 2001 heralded the coming of the post-genomic era, and also set off a new wave of RNA research. As the new frontier in the post-genomic era, RNomics are now a highlight in the life science, the discovery of diverse ncRNA challenge the traditional understanding that proteins are the only effectors of gene function. To display the latest progress in RNA research, the third issue of Science in China Series C-Life Sciences(2009) focus on non-coding RNA and RNomics with 8 review notes, covering the sncRNAs in animals and plants, miRNA in oncogenesis, cell differentiation and development, RNA targets for diagnosis and therapy, mRNA splicing, RNAs involved in genomic imprinting and evolution of ncRNA genes. This special topic shows the latest advances and some perspective on the non-coding RNA research field.