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Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape
Authors:Stosich Michael S  Moioli Eduardo K  Wu June K  Lee Chang Hun  Rohde Christine  Yoursef Azizeh Mitra  Ascherman Jeffrey  Diraddo Robert  Marion Nicholas W  Mao Jeremy J
Institution:Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Engineering, Columbia University Medical Center, College of Dental Medicine, New York, NY 10032, USA.
Abstract:Tissue engineering offers the possibility for soft tissue reconstruction and augmentation without autologous grafting or conventional synthetic materials. Two critical challenges have been addressed in a number of recent studies: a biology challenge of angiogenesis and an engineering challenge of shape maintenance. These two challenges are inter-related and are effectively addressed by integrated bioengineering strategies. Recently, several integrated bioengineering strategies have been applied to improve bioengineered adipose tissue grafts, including internalized microchannels, delivery of angiogenic growth factors, tailored biomaterials and transplantation of precursor cells with continuing differentiation potential. Bioengineered soft tissue grafts are only clinically meaningful if they are vascularized, maintain shape and dimensions, and remodel with the host. Ongoing studies have begun to demonstrate the feasibility towards an ultimate goal to generate vascularized soft tissue grafts that maintain anatomically desirable shape and dimensions.
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