Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246 |
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| Authors: | Shiono Yoshihito Shimanuki Keiko Hiramatsu Fuminori Koseki Takuya Tetsuya Murayama Fujisawa Nozomi Kimura Ken-ichi |
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| Institution: | Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Wakabamachi 1-23, Tsuruoka, Yamagata 997-8555, Japan. yshiono@tds1.tr.yamagata-u.ac.jp |
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| Abstract: | Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher's method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells. |
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