Signaling-mediated bacterial persister formation |
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Authors: | Vega Nicole M Allison Kyle R Khalil Ahmad S Collins James J |
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Affiliation: | Howard Hughes Medical Institute, Boston University, Boston, Massachusetts, USA. |
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Abstract: | Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics and identify the role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling 'inoculates' a bacterial subpopulation against antibiotics by activating stress responses, leading to persister formation. |
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