Inhibition of replicative DNA synthesis in nuclei of Strongylocentrotus intermedium urchin embryo by 2′,3′-dideoxy-3′-aminonucleoside 5′-triphosphates |
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| Authors: | M. Kukhanova A. Krayevsky N. Terentyeva V. Rasskazov |
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| Affiliation: | 1. Institute of Molecular Biology of the USSR Academy of Sciences, Vavilov str., 32, Moscow B-334, 117984, U.S.S.R.;2. The Pacific Ocean Institute of Bioorganic Chemistry of the USSR Academy of Sciences, Pr. Stoletia 156, Vladivostok, 690022 U.S.S.R. |
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| Abstract: | 2′,3′-Dideoxy-3′-aminonucleoside 5′-triphosphates have been shown to be inhibitors of replicative DNA synthesis in isolated nuclei of sea urchin embryo. These compounds inhibit the Okazaki fragment synthesis. The effect of 2′,3′-dideoxy-3′-aminothymidine 5′-triphosphate and arabinothymidine 5′-triphosphate is reversible when adding the corresponding substrate for DNA synthesis, 2′-deoxythymidine 5′-triphosphate. |
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| Keywords: | DNA synthesis Dideoxyaminonucleotide Nucleotide derivative Okazaki fragment (Sea urchin) |
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