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Fulminant cryptosporidiosis associated with digestive adenocarcinoma in SCID mice infected with Cryptosporidium parvum TUM1 strain |
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| Authors: | Gabriela Certad Colette Creusy Anthony Mouray Baptiste Delaire Ariadna Sitja-Bobadilla Marleen Praet Eduardo Dei-Cas |
| Affiliation: | a Laboratoire Biologie et Diversité des Pathogènes Eucaryotes Émergents (BDEEP), Institut Pasteur de Lille (IFR 142)-Univ Lille Nord de France (EA4547), France b Cátedra de Parasitología, Escuela de Medicina “José María Vargas”, Universidad Central de Venezuela (UCV), Caracas, Venezuela c Service d’Anatomie et de Cytologie Pathologiques, Groupe Hospitalier de l’Université Catholique de Lille, France d Plateau d’Expérimentation Animale, Institut Pasteur de Lille, France e Unité de Sécurité Microbiologique, Institut Pasteur de Lille, France f Instituto de Acuicultura de Torre la Sal, Ribera de Cabanes, Castellón, Spain g Academic Department of Pathology, Ghent University, Ghent, Belgium h Parasitologie-Mycologie, Centre Hospitalier Régional et Universitaire de Lille, Univ Lille Nord de France, France |
| Abstract: | We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 strain developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum-induced gastro-intestinal cancer in humans should be assessed. |
| Keywords: | Cancer Cryptosporidium parvum TUM1 Fulminant infection Intestinal adenocarcinoma Intraepithelial neoplasia SCID mice |
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