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Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon |
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| Authors: | Emmanuel Assana Charles G. Gauci Pierre Dorny Garry A. Anderson Marshall W. Lightowlers |
| Affiliation: | a Institute of Tropical Medicine, Department of Animal Health, Nationalestraat 155, B-2000 Antwerpen, Belgium b Veterinary Clinical Centre, The University of Melbourne, 250 Princes Hwy, Werribee, Vic. 3030, Australia c University of Dschang, Faculty of Agronomy and Agricultural Sciences, P.O. Box 222, Dschang, Cameroon |
| Abstract: | A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 μg TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P < 0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans. |
| Keywords: | Taenia solium Vaccination Pigs TSOL18 Field trial Cameroon |
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