Tick-susceptible Bos taurus cattle display an increased cellular response at the site of larval Rhipicephalus (Boophilus) microplus attachment, compared with tick-resistant Bos indicus cattle |
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Authors: | Emily K Piper Louise A Jackson Helle Bielefeldt-Ohmann Cedric Gondro Ala E Lew-Tabor Nicholas N Jonsson |
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Institution: | a Cooperative Research Centre for Beef Genetic Technologies, Armidale 2351, Australia b The University of Queensland, School of Veterinary Science, Brisbane 4072, Australia c Queensland Primary Industries and Fisheries, Brisbane 4105, Australia d The University of New England, The Institute for Genetics and Bioinformatics, Armidale 2351, Australia e Murdoch University, Centre for Comparative Genomics, Perth 6105, Australia |
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Abstract: | Cattle demonstrate divergent and heritable phenotypes of resistance and susceptibility to infestation with the cattle tick Rhipicephalus (Boophilus) microplus. Bos indicus cattle are generally more resistant to tick infestation than Bos taurus breeds although large variations in resistance can occur within subspecies and within breed. Increased tick resistance has been previously associated with an intense hypersensitivity response in B. taurus breeds; however, the mechanism by which highly resistant B. indicus cattle acquire and sustain high levels of tick resistance remains to be elucidated. Using the commercially available Affymetrix microarray gene expression platform, together with histological examination of the larval attachment site, this study aimed to describe those processes responsible for high levels of tick resistance in Brahman (B. indicus) cattle that differ from those in low-resistance Holstein-Friesian (B. taurus) cattle. We found that genes involved in inflammatory processes and immune responsiveness to infestation by ticks, although up-regulated in tick-infested Holstein-Friesian cattle, were not up-regulated in Brahman cattle. In contrast, genes encoding constituents of the extracellular matrix were up-regulated in Brahmans. Furthermore, the susceptible Holstein-Friesian animals displayed a much greater cellular inflammatory response at the site of larval R. microplus attachment compared with the tick-resistant Brahman cattle. |
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Keywords: | Rhipicephalus (Boophilus) microplus Tick Skin gene expression Cattle |
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