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Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia |
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| Authors: | N. Parameswaran N. Sundar M. Johnson M.E. Grigg |
| Affiliation: | a WHO Collaborating Centre for the Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia b Molecular Parasitology Unit, Laboratory of Parasitic Diseases, National Institutes of Health, NIAID, 4 Center Drive, Bethesda, MD 20892, USA c Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, NSW 2007, Australia |
| Abstract: | Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia’s isolation may have favoured the persistence of non-archetypal ancestral genotypes. |
| Keywords: | Toxoplasma gondii Non-archetypal Genotype Australia Wildlife Marsupials |
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