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A DNA microarray survey of gene expression in normal human tissues |
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| Authors: | Radha?Shyamsundar Young?H?Kim John?P?Higgins Kelli?Montgomery Michelle?Jorden Anand?Sethuraman Matt?van de Rijn David?Botstein |
| Institution: | (1) Department of Pathology, Stanford University School of Medicine, 269 Campus Drive, CCSR 3245A, Stanford, CA 94305-5176, USA;(2) Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305-5307, USA;(3) Department of Genetics, Stanford University, Stanford, CA 94305, USA;(4) Howard Hughes Medical Institute, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305-5307, USA;(5) Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 80544, USA |
| Abstract: | BackgroundNumerous studies have used DNA microarrays to survey gene expression in cancer and other disease states. Comparatively little is known about the genes expressed across the gamut of normal human tissues. Systematic studies of global gene-expression patterns, by linking variation in the expression of specific genes to phenotypic variation in the cells or tissues in which they are expressed, provide clues to the molecular organization of diverse cells and to the potential roles of the genes. |
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