Translocation (Y;19)(q12;q13) and azoospermia |
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| Authors: | L R Diaz-Casta?os H Rivera R M Gonzalez-Montes M Diaz |
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| Institution: | División de Genética, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco. |
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| Abstract: | An azoospermic male with a 46,X,t(Y;19)(q12;q13) karyotype is described. The comparison with 12 similar cases reveals that the Y breakpoints are usually on the long arm whereas the autosomal ones seem to be at random. Since a premeiotic origin is inconsistent with the arrest at diakinesis seen in those cases with meiotic studies, we postulate that a balanced t(Y;A) arises either via a chromatid exchange in the meiotic interphase or through a chromosome exchange in spermiogenesis or at the one cell stage of the zygote. |
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