In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR62) to 16p12–16p13.1 |
| |
Authors: | T Gress A Baldini M Rocchi H Furneaux J B Posner M Siniscalco |
| |
Institution: | Imperial Cancer Research Fund, London, Great Britain. |
| |
Abstract: | A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the synteny of the gene with the autosome 16, we proceeded to its precise subregional mapping by in situ fluorescence hybridization with a recombinant lambda phage containing the genomic region homologous to the cDNA gene. The latter studies pin-pointed the chromosomal localization of the structural CDR62 gene within the interval 16p12-16p13.1. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |