Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands |
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Authors: | Tahara-Hanaoka Satoko Miyamoto Akitomo Hara Ayumi Honda Shin-ichiro Shibuya Kazuko Shibuya Akira |
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Institution: | Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, Center for TARA, University of Tsukuba, Ibaraki 305-8575, Japan. |
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Abstract: | The leukocyte adhesion molecule DNAM-1 (CD226) is a member of the immunoglobulin superfamily and constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes/macrophages, and a subset of B lymphocytes. The poliovirus receptor (PVR; CD155) and its family member nectin 2 (CD112) have recently been identified as the ligands for DNAM-1. Interaction of DNAM-1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. However, in vivo function of the receptor-ligand interaction has remained unclear. Here, we identified murine DNAM-1 and PVR homologues that physically and functionally bind each other. We demonstrated that ligand binding of murine DNAM-1 induced a costimulatory signal in antigen-specific CD8+ T cells. These results should provide a useful animal model to explore a role of DNAM-1 in immune responses in vivo. |
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Keywords: | DNAM-1 CD226 Poliovirus receptor Nectin-2 PRR-2 NK cells T cells Costimulatory molecule |
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