Interactions between GABAergic and cholinergic mechanisms involved in monocular optokinetic nystagmus in frogs] |
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Authors: | N Bonaventure B Jardon |
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Institution: | Laboratoire de Neurophysiologie et Biologie des Comportements, U.P.R. n. 419 du C.N.R.S., Strasbourg. |
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Abstract: | The systemic administration of atropine, a muscarinic cholinergic antagonist, was found to suppress the Nasal-Temporal (N-T) component of the frog monocular optokinetic nystagmus (OKN), which had appeared following a prior injection of bicuculline and which does not exist in the normal animal. On the contrary, the administration of a nicotinic cholinergic antagonist (D-TC, alpha-BGT, Hexamethonium) following that of bicuculline has prolonged the duration of the induced N-T component. Thus, ACh was shown to attenuate or to reinforce the GABAergic inhibition of the N-T component through muscarinic receptors or nicotinic receptors respectively. These data point to the existence of strong interactions between these two neurotransmission systems involved in frog monocular OKN. |
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