Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans |
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| Institution: | 1. Arizona Prevention center, University of Arizona, School of Medicine, Tucson, AZ 85724, USA;2. Department of Obstetrics and Gynecology, University of Arizona, School of Medicine, Tucson, AZ 85724, USA;3. Department of Biochemistry, University of Arizona, School of Medicine, Tucson, AZ 85724, USA;1. Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China;2. Department of Reproductive Center, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi Zhuang Autonomous Region, China;1. Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, 625021, Tamil Nadu, India;2. National Centre for Nanoscience and Nanotechnology, University of Madras, Guindy campus, Chennai, 25, India;3. Student training Unit, Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia;1. Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Poland;2. Clinic of Gynecology and Urogynecology, Pomeranian Medical University in Szczecin, Poland;1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran;3. Gynecologist and fellowship of infertility assistant professor of OB & GYN of Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65–82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3 %. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels. |
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