Effect of isradipine,a dihydropyridine-calcium antagonist on I.V. self-administration of morphine in rats |
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| Institution: | 2. St.-Petersburg Pavlov Medical University, Russia;1. University of Cagliari, Italy;1. University of Milano, 20122 Milano, Italy;2. Department of Clinical Sciences and Community Health, University of Milano, 20122 Milano, Italy;3. Department of Woman, Newborn and Child, Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico, Milano, Italy;4. Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy;1. Department of Zoology and Anthropology, Constantine The Philosopher University in Nitra, 949 74 Nitra, Slovakia;2. Department of Genetics and Reproduction, Research Institute of Animal Production Nitra, 951 41 Lužianky, Slovakia;3. Zoology Department, College of Science, King Saud University, College of Sciences, Riyadh 11451, Saudi Arabia;1. Channing Division of Network Medicine, Harvard Medical School & Brigham and Women''s Hospital, USA;2. Departments of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA;3. Departments of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA;4. Departments of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, USA;5. Departments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA;6. Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;7. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA;8. Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, USA |
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| Abstract: | The effect of dihydropyridine calcium channel antagonist isradipine (PN 200-110) on morphine reinforcement has been investigated using i.v. self-administration test in rats. Rats were given the opportunity to self-administer a solution of morphine (1 mg/Ml, i.v.) in a 1 hr limited access paradigm (FR = 1). Within 5–7 days rats had learned to self-administer approximately 1 mg of morphine in 1 hr as evidenced by a plateau of responding. The administration of isradipine (1.2, 2.5 and 5.0 mg/kg s.c.) 90 min before the morphine self-administration session, induced dose-dependent increase in the number of morphine self-infusions with respect to basal values. This response pattern was very similar to the one observed when morphine solution was substituted by saline in trained rats not treated with isradipine. The results indicate that isradipine inhibits partially the reinforcing properties of morphine in self-administration test. |
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