Iridoid glucosides in Plantago alpina and P. Altissima |
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| Institution: | 1. Department of Organic Chemistry, The Technical University of Denmark, DK-2800 Lyngby, Denmark;2. Department of Chemistry, The Royal Veterinary and Agricultural University, DK-1871 Frederiksberg C, Denmark;3. Botanic Garden, University of Copenhagen, DK-1307 Copenhagen, Denmark;1. College of Pharmacy, Dongguk University, Goyang, Gyeonggi-do 410-773, Republic of Korea;2. Department of Pharmaceutical Science and Engineering, Seowon University, Cheongju, Chungbuk 361-742, Republic of Korea;1. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;2. College of Traditional Mongolian Medicine, Inner Mongolia Medical University, Hohhot 010110, China;3. College of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010110, China;4. Department of Chemistry, Myong Ji University, Myongji 449-728, Republic of Korea;5. Department of Biomedical Sciences, University of Veterinary Medicine, Vienna 1210, Austria;1. ICMR-UMR CNRS 7312, Groupe Isolement et Structure, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;2. Laboratoire de Chimie Organique Biologique, 01 BPV 34 Abidjan 01, Université Félix-Houphouët Boigny d’Abidjan-Cocody, Cote d’Ivoire;3. ICMR-UMR CNRS 7312, Service Commun d’Analyses, Campus Sciences, Bât. 18, BP 1039, 51687 Reims Cedex 2, France;1. Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, PR China;2. State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, PR China;3. Guangdong Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, PR China;4. School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, Sichuan, PR China;1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;3. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;4. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Abstract: | Two species of Plantago, namely P. Alpina and P. altissima were investigated. From the former, nine iridoid glucosides and verbascoside were isolated. Together with the known iridoids gardoside, geniposidic acid, 8-epi-loganic acid, mussaenosidic acid, aucubin, monomelittoside and melittoside, two new glucosides were found: 10-O-acetylgeniposidic acid and alpinoside, another compound with a 10-O-acetyl group. From P. altissima verbascoside and isoverbascoside were isolated together with the known iridoids gardoside, 8-epi-loganic acid, catalpol, aucubin, and hookerioside as well as the new compound desacetylhookerioside. |
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