On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems |
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Authors: | Lan K Nguyen Don Kulasiri |
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Affiliation: | (1) Centre for Advanced Computational Solutions (C-fACS), Lincoln University, Christchurch, New Zealand |
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Abstract: | Background Feedback regulation plays crucial roles in the robust control and maintenance of many cellular systems. Negative feedbacks are found to underline both stable and unstable, often oscillatory, behaviours. We explore the dynamical characteristics of systems with single as well as coupled negative feedback loops using a combined approach of analytical and numerical techniques. Particularly, we emphasise how the loop's characterising factors (strength and cooperativity levels) affect system dynamics and how individual loops interact in the coupled-loop systems. |
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