Chemical constituents from Tribulus terrestris and screening of their antioxidant activity |
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| Affiliation: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Egypt;2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA;3. Department of Pharmaceutics, School of Pharmacy, University of Mississippi, University, MS 38677, USA;1. College of Pharmacy, Xi’an Jiaotong Univeristy, Xi’an 710061, China;2. Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi’an 710069, China;3. Laboratory of Bioseparation Technology, Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA;1. Departamento de Cirugía (Urología), Facultad de Ciencias Médicas, Universidad Estatal de Campinas UNICAMP, São Paulo, Brasil;2. Facultad de Medicina (Urología), Centro de Ciencias de la Vida, Universidad Católica de Campinas PUC-Campinas, São Paulo, Brasil;1. Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Gov., Egypt;2. Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Sharkia Gov., Egypt;3. Department of Biochemistry, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Sharkia Gov., Egypt;1. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Fertility & Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Infertility Treatment Research Center, Moatazedi Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran |
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| Abstract: | Two oligosaccharides (1, 2) and a stereoisomer of di-p-coumaroylquinic acid (3) were isolated from the aerial parts of Tribulus terrestris along with five known compounds (4–8). The structures of the compounds were established as O-β-d-fructofuranosyl-(2 → 6)-α-d-glucopyranosyl-(1 → 6)-β-d-fructofuranosyl-(2 → 6)-β-d-fructofuranosyl-(2 → 1)-α-d-glucopyranosyl-(6 → 2)-β-d-fructofuranoside (1), O-α-d-glucopyranosyl-(1 → 4)-α-d-glucopyranosyl-(1 → 4)-α-d-glucopyranosyl-(1 → 2)-β-d-fructofuranoside (2), 4,5-di-p-cis-coumaroylquinic acid (3) by different spectroscopic methods including 1D NMR (1H, 13C and DEPT) and 2D NMR (COSY, TOCSY, HMQC and HMBC) experiments as well as ESI-MS analysis. This is the first report for the complete NMR spectral data of the known 4,5-di-p-trans-coumaroylquinic acid (4).The antioxidant activity represented as DPPH free radical scavenging activity was investigated revealing that the di-p-coumaroylquinic acid derivatives possess potent antioxidant activity so considered the major constituents contributing to the antioxidant effect of the plant. |
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| Keywords: | Zygophyllaceae Oligosaccharides Antioxidant activity DPPH |
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