Effects of CCK-8 in the nucleus accumbens |
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| Authors: | J F DeFrance R W Sikes R B Chronister |
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| Institution: | 1. Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77025, USA;2. Department of Anatomy, University of South Alabama, Mobile, AL 36688, USA |
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| Abstract: | The electrophysiological effects of CCK-8 were studied in the rabbit nucleus accumbens. CCK-8 was found to influence neurotransmitter (modulator) systems so as to enhance their action. For example, CCK-8 enhanced the effects of stimulation of the glutaminergic pathways, the fimbria. In addition, when CCK-8 was co-administered with dopamine and acetylcholine, their suppressive effect on the fimbria evoked response was enhanced. Therefore, CCK-8 appears to be capable of enhancing the influence of multiple neurotransmitter (modulator) systems. |
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| Keywords: | Nucleus accumbens CCK-8 Dopamine Acetylcholine |
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